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Epidermal growth factor-like domain-containing protein 7 (EGFL7) enhances EGF receptor-AKT signaling, epithelial-mesenchymal transition, and metastasis of gastric cancer cells

Maiti A, DiNardo CD, Rausch CR, Cortes JE, Pemmaraju N, Daver NG, Ravandi F, Garcia-Manero G, Borthakur GM, Naqvi K, Ohanian MN, Short NJ, Alvarado Y, Benton CB, Kadia TM, Takahashi K, Yilmaz ME, MD, Jain N, Kornblau SM, Sasaki K, Andreeff M , Bose P, Ferrajoli A, Issa GC, Jabbour E, Masarova L, Rytting ME, Thompson PA, Wang SA, Konoplev S, Chen Z, Goswami M, Maduike R, Guerrero JA, Zhang Q, Cavazos A, Ma H, Bivins CA, Wade A, Adewale SL, Tse S, Thomas R, Vaughan K, Pierce SA, Ning J, Qiao W, Welch JS, Kantarjian HM, Konopleva MY

This does not mean higher doses are beneficial, only that accidental overdose within reasonable ranges carries minimal acute risk

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Protocol Overview The honest overview is short

However, to date, the methods used to increase GPx expression are mainly the artificial over-expression of GPxs through transfections or infections