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Semaglutide 2.4 mg (Wegovy, FDA-approved for weight management) reports diarrhea in approximately 30% of patients in clinical trials according to the FDA prescribing information

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Absolute contraindications to GLP-1 receptor agonists with the boxed warning include patients with a personal history of MTC, family history of MTC, or known MEN 2 syndrome

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This is an immediate discard signal