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Preclinical studies have shown that GLP-1 receptor agonism can attenuate alcohol-induced locomotor stimulation and accumbal dopamine release, reduce nicotine-associated reward behaviors, and suppress cocaine seeking or self-administration in rodent models [18-21]
Longer-term data from participants who stayed on treatment points the same direction from the opposite angle: three-year results from the SURMOUNT-1 trial, published in the New England Journal of Medicine , tracked sustained outcomes in people who continued therapy rather than stopping it
However, safety always depends on your individual medical history
Slower dose escalation or short treatment pauses may improve tolerance 9,15
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