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[8] [10] The underlying pathophysiology involves changes in the hypothalamic thermoregulatory centre
The review emphasizes the diverse functions of glutathione, including its role as an antioxidant, regulator of DNA synthesis, and protector of proteins, highlighting its significance in maintaining brain health and combating neurodegeneration These recent scientific studies underscore the importance of glutathione in neurological health and its potential therapeutic implications in various neurological disorders by addressing oxidative stress, neuroinflammation, and neuronal damage 7
Evidence is promising but pre-clinical
Cartilage loss & OA progression : Studies published in journals like Radiology (2017) and JAMA (2017) have shown repeated intra-articular cortisone to accelerate cartilage loss and faster osteoarthritis progression, even if pain improves short term
Recently, Semaglutide was also FDA-approved for weight loss
Likewise, FGF21 administration inhibits formation of bleomycin-induced pulmonary fibrosis in vivo by suppressing oxidative stress via NRF2 activation, and inhibiting TGF--induced activation of pulmonary myofibroblasts (224)
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