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doi: 10.1074/jbc.M112.341248 61 AdamsACKharitonenkovA
Semaglutide and orforglipron act on the same single targetso this group may have maintained weight loss better after switching treatments, but they started with a less dramatic weight loss
The physiological effects of GLP-1 include stimulating insulin secretion in a glucose-dependent manner (Holz Iv et al 1993), inhibiting glucagon release, and slowing gastric emptying
For electrophysiological studies, male pathogen-free mice at an age of 618 weeks were used for all experiments
Data availability The datasets analysed during the current study are not publicly available because they are register-based and contain information about individual patients
This was further confirmed in vitro using human vascular endothelial cells
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