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Robert Kushner: That article has been a paradigm shift and there's been so many follow-up articles in response to it with other types of studies that are addressing it

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Missing More Than 2 Weeks: If more than 2 consecutive doses are missed, the patient should effectively restart the titration or consult their physician, as tolerance may have been lost

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As an important channel of essential oxygen and energy sources for the brain, cerebral microvessels are an important component of the bloodbrain barrier (BBB), and its disruption is an early pathophysiological mechanism in neurodegenerative diseases (20)

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Dose-Response Relationships In animal stroke models, gene expression changes occurred 1-24 hours post-administration, but whether similar timing applies to psychiatric effects is unknown

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