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Amylin and Calcitonin Receptor Pathway Satiety Enhancement Cagrilintide acts as a nonselective agonist of amylin receptors (AMY1R, AMY2R, AMY3R) and calcitonin receptor (CTR), mimicking the satiety-inducing effects of endogenous amylin[3]

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the K i values ( standard deviation) for PAT were 4.86 0.46 nM (TrxR activity) or 7.22 4.96 nM (GR activity), and for OPZ were 18.1 1.1 M (TrxR activity) or 33.8 6.0 M (GR activity)

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