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The heart of the system is a disposable, high-precision molded polycarbonate microfluidic chip containing a 25-l PCR chamber connected to a network of microfluidic channels 15

M., Vazquez, G., Duval, S

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173 At the molecular level, gene modulation techniques, including siRNA- and shRNA-mediated silencing of efflux transporter genes (e.g., ABCB1, ABCG2), as well as CRISPR/Cas9-based gene editing, have successfully resensitized tumor cells to chemotherapy in preclinical models

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Melanin is responsible for the appearance of dark spots and uneven skin tone