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(2022) determined that the negative effects of SSRIs on male fertility were both dose- and treatment-dependent, with the greatest impact observed at high doses and following prolonged exposure, although the effects were reversible after discontinuation (Figure 1)
& Verlinsky, Y
Apart from external inducers, endogenous triggers such as mast cell-derived histamine, proteases and eicosanoids can increase intestinal permeability, either directly or via stimulation of neurons of the enteric nervous system [194],[199],[200]
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