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In patients with HFpEF and obesity, both semaglutide (STEP-HFpEF) and tirzepatide (SUMMIT) significantly reduced cardiovascular death and worsening heart failure events, with concomitant improvements in quality of life and functional capacity [3,47]
And it appears that active individuals get more of a benefit than those who live a sedentary lifestyle
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Remember that NICE guidelines emphasise individualised care for weight management