Many people lose a significant amount of weight with the medications
Regul Pept 181:5066 Bdis B, Kardi O, Nmeth P, Dohoczky C, Kolega M, Mzsik G (1997) Evidence for direct cellular protective effect of PL-10 substances (synthesized parts of body protection compound, BPC) and their specificity to gastric mucosal cells
Longer use may need periodic zinc and liver checks
Current prescribing information includes warnings related to elevated IGF-1, glucose intolerance, fluid retention, malignancy risk, hypersensitivity, and injection-site reactions. A complete safety discussion belongs in a separate article, but these limitations are essential when interpreting potential benefits
In non-human research, it has shown relevance in the regulation of gene expression tied to regeneration, collagen production, and oxidative stress recovery
Safety and efficacy of Efruxifermin in combination with a GLP-1 receptor agonist in patients with NASH/MASH and type 2 diabetes in a randomized phase 2 study