The potential for gastrointestinal adverse effects, particularly nausea and vomiting, may lead to dehydration and worsening of renal function in vulnerable patients
When combined with healthy lifestyle changes, GLP-1 medications can help people achieve steady, long-term weight loss
On one hand, IBD can lead to dysregulation of adipokines, shifting the balance towards a pro-inflammatory state, on the other hand obesity and higher BMI are associated with higher risk of developing IBD and worse clinical outcomes, particularly for UC
Given that both of these studies were in patients with OA of the knee (a load-bearing joint), it is likely that a significant proportion of the efficacy observed was due to the significant loss of body weight, reducing pathological joint loading
Statpearls Publishing, Treasure Island FL (2025)
Glutathione is a powerful antioxidant naturally produced by the liver, known for its skin-lightening and anti-aging benefits