Tirzepatide-based evidence from the SURPASS (Researching Tirzepatide in Patients with Type 2 Diabetes for Glycemic Control and Weight Management) trials (SURPASS-1 NCT03954834 and SURPASS-5 NCT04039503) demonstrated dose-dependent, significant weight loss over 40 weeks compared with placebo, along with reductions in BMI and waist circumference [62, 63]
4) Price and reimbursement: If long-term dose is necessary for patients, price will become prominent when more GLP-1-RAs enter the market, which means patients have more choices
Nutritional Biochemistry
Its reductive half-reaction with GSH has a rate constant of 1.2 10 5 M 1 s 1 , which is ten times slower than the oxidative half-reaction with GSSCys
The company offers a range of GLP-1 medications, including Wegovy, Zepbound vials, Zepbound, Mounjaro, Ozempic, Trulicity, Victoza, and Saxenda
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