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do not shake vigorously, as this can cause denaturation or aggregation of the peptide

This dual mechanism is why tirzepatide consistently outperforms semaglutide in head-to-head trials

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10.1016/j.freeradbiomed.2011.01.038 23 MarM.de GregorioE.de DiosC.Roca-AgujetasV.CucarullB.TutusausA.et al (2020)

Likewise, mothers who are breastfeeding are advised against NAD+ therapy because its unknown if or how NAD+ might pass into breast milk and affect the baby