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The overaccumulation of triacylglycerol and cholesterol in the hepatocytes and the overproduction of reactive oxygen species (ROS) both lead to local inflammatory responses
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Substitution with Tyr 13 scarcely affects the activity of GIP (114) analogues, 33 implying that the use of Tyr 13 in the designed dual agonist may not conspicuously affect GIP activity
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