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Sirtuin activators mimic caloric restriction and delay ageing in metazoans

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Studies have shown in mouse models that high-dose Erastin reduces red blood cells and hemoglobin, suppresses bone-marrow cellularity, and depletes hematopoietic stem and progenitor populations that are highly sensitive to ferroptosis (90, 91)

This explains why high levels of oxidative stress is implicated not just in neurodegenerative conditions but cardiovascular diseases as well

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