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The gradual weight reduction typically achieved with these medications has not been associated with clinically significant changes in thrombotic risk in clinical trials

While it is recommended that women discontinue GLP-1s before pregnancy, the drugs increasingly widespread use means that inadvertent exposure during the first trimester is becoming more common

doi: 10.1111/jdv.14987 30

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8.6 Renal Impairment BYETTA is not recommended for use in patients with end-stage renal disease or severe renal impairment (creatinine clearance 7.0% entered a 30-week intervention phase and were randomized to add either BYETTA or insulin lispro to their existing regimen of insulin glargine and metformin