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The FLOW trial (Perkovic et al., New England Journal of Medicine , 2024) specifically studied semaglutide in CKD patients and found no need for dose adjustment
This strategy typically includes lifestyle modifications like diet and exercise
Both carry a boxed warning regarding thyroid C-cell tumors based on rodent studies and are contraindicated in patients with a personal or family history of medullary thyroid cancer or MEN 2
Athauda D, Maclagan K, Skene SS, et al
MicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells
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