Food and Drug Administration (FDA) on the 1st approved 'Foundayo (ingredient name: orforglipron),' an oral obesity treatment developed by Eli Lilly, the company that supplies the obesity drug 'Mounjaro.' This is the second oral GLP-1 class obesity treatment to be approved, following the pill form of Novo Nordisk's 'Wegovy' last December
For example, in tumor cells, this change in the acidbase gradient between the inside and outside of the cell reduces the diffusion of weakly alkaline anticancer drugs into the cell [246]
While all GLP-1 medications effectively lower hemoglobin A1c and promote weight loss, they differ in dosing frequency, formulation, cardiovascular benefits, and side effect profiles
In trials, the incidence ranged from mild to moderate, and it was not the most frequent side effect
Older adults may need dose adjustments or extra monitoring, especially if they have kidney problems or take other medicines