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Lower doses or careful monitoring may be necessary to avoid accumulation and increased side effects

Important warnings from the SmPC include: Risk of hypoglycaemia when used with insulin or sulphonylureasdose adjustments of these medications may be needed Volume depletion and acute kidney injury risk with severe gastrointestinal symptoms Reduced exposure to oral contraceptives during initiation and dose increasesconsider using non-oral or additional barrier contraception More serious but less common adverse effects include pancreatitis (inflammation of the pancreas)

Sharvil Patel of Zydus described the strategy: We have launched a novel formulation on sema

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