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The mechanism appears to be interference with erythropoiesis

Animal studies in diet-induced obese rats show tesofensine (2.0mg/kg) produces marked weight reduction accompanied by strong hypophagic responses

For individuals with a significant B-12 deficiency, B-12 injections are typically administered weekly until levels normalize

refrigeration at 4 C (39 F) is acceptable for short-term storage (days to weeks)

Linkage between the cecal microbiome and adipose tissue metabolome The relative abundance of a large number of microbial genera correlated with EWAT metabolite abundances

The path forward For 5-amino-1mq to move from research compound to established therapy, human clinical trials are needed