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For people coming off other GLP-1s (semaglutide or tirzepatide), you have some receptor adaptation already
Jimbow, K., Roth, S
Furthermore, a recent scientific statement from the American Heart Association (AHA) noted that dysautonomia patients exhibiting severe exercise intolerance frequently had notably abnormal levels of plasma carnitine-conjugated and free fatty acids
None of these look anything like a large GLP-1 analog peptide under the antibody-based assays used in standard testing
One small study found that a cream containing 5% ALA helped reduce fine lines on the face due to sun damage when used for 12 weeks