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40 (Phase 3), FDA/EMA GLP-1 / GIP / , (Ozempic) (Mounjaro) 40 12 ~24% 48 (Phase 2, NEJM 2023) Mounjaro 15 (~2226%) , : , Phase 3 (Retatrutide) 40 (ALLUVI) 1 - ALLUVI Retatrutide (40 , 10 ), 12 ALLUVI (Dosage Guide) 2.5 10
received research funding (paid to the institution) from Merck, Bristol Myers Squibb, and Boehringer-Ingelheim
doi: 10.1093/nutrit/nuae131 8 AlvesIArajoEMQDalgaardLTSinghSBrsheimECarvalhoE
Several of the tested cases presented a hypermutation phenotype, resulting in a high mutation burden of mismatch repair genes
Some report success maintaining weight through lifestyle changes alone, but most highlight a rapid return of hunger and weight regain if medication is stopped abruptly, underscoring the need for structured support when adjusting or discontinuing treatment
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