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These are different chemical entities
The second mechanism includes the development of hyperplasia (an increase in the number of muscle fibers)
In the gastrointestinal tract, COX-1-derived prostaglandins function to increase production of the thick mucus/bicarbonate layer that coats gastric surfaces and buffers them against stomach acid (Vonkeman 2010)
GLP-1 medications are not appropriate for everyone, and we screen for these during your consultation: Pregnant or breastfeeding women GLP-1 medications should be stopped at least 2 months before a planned pregnancy
We also see discontinuation related to tolerability, particularly gastrointestinal side effects, and less commonly when patients reach a weight or glycemic goal and want to stop
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