Its preliminary, but you can see that countries that have more ergothioneine in their diets, countries like France and Italy, also have lower incidences of neurodegenerative diseases, while people in countries like the United States, which has low amounts of ergothioneine in the diet, have a higher probability of diseases like Parkinsons Disease and Alzheimers, Beelman said.
Oct 2018;29(10):987-994
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However, since supplements arent regulated by the FDA, its not always possible to determine the type, quantity, and quality of the ingredients in a product
Methylcobalamin: Metabolites of vitamin B12 are formed by this process
Within the substantia nigra (largest of four nuclei in the basal ganglia of the midbrain), and some other regions of the brain, synthesis proceeds only to dopamine