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The primary reason is still sustainable weight change under medical supervision

Telomere shortening is one hallmark of aging among many (genomic instability, epigenetic drift, mitochondrial dysfunction, cellular senescence, loss of proteostasis, stem-cell exhaustion, and others), and the relationship between telomere length, telomerase activity, healthspan, and cancer risk is complex and bidirectional in several mammalian settings, more telomerase means more, not less, cancer

These symptoms can lead to dehydration, electrolyte imbalances, and inadequate nutrition, all of which may manifest as fatigue

Basal energy expenditure (BEE) was higher in LowEBMIL, but without difference between groups ( p = 0.226) when adjusting for lean mass in the ANOVA

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