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The weight loss was augmented by the addition of GCGR-mediated increases in energy expenditure to GIPR- and GLP-1R-driven calorie intake reduction

1 Despite the availability of multiple treatments, a substantial proportion of patients either fail to achieve remission, particularly in cases of treatment-resistant depression (TRD) and late-life depression

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To assess the impact of the failed gut surface area expansion in male GLPDRKO mice on dietary fat handling, a lipid tolerance test was performed following a 5 h fast