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Sci Rep 12 , 15975 (2022)

Hruby and Mac Hadley (University of Arizona, USA) in 19871989 Original development program Competitive Technologies Palatin Technologies , later spun off into PT-141 (bremelanotide) Target: non-selective agonist of MC1R, MC3R, MC4R, MC5R (more potent than -MSH, longer half-life) Standard experimental dose in human tanning studies: 0.025 mg/kg subcutaneously (Dorr 1996) In Dorr 1996 (n=10): increase in skin melanin density measured by colorimetry by ~25 % after a 10-day course Main adverse effects in the preclinical literature: nausea, flushing, hyperpigmentation (including atypical nevi), priapism Approximately 100+ publications in PubMed

What is astaxanthin?Astaxanthin is a powerful antioxidant that belongs to a group of natural pigments called xanthophylls, that in turn belong to a su

Berk M, et al

Without sufficient L-Carnitine: Fat cannot efficiently enter mitochondria Fat burning becomes slower This is where supplementation becomes useful

Curettage and electrodesiccation: The tumor is cut from the skin with a curette (a sharp, spoon-shaped tool)