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We used our model to test the importance of glucoronidation and its sensitivity to the activity of the glucoronosyl tranferase enzymes by computing the amount of liver damage resulting from a moderate overdose (10 g) with different choices for the V max values of the glucoronosyl tranferases

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Furthermore, emerging evidence indicates that TJ protein alterations may also contribute to BBB dysfunction in psychiatric conditions such as bipolar disorder and schizophrenia, where they are associated with cognitive impairments and neuroinflammation [286]

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