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Semaglutide slows gastric emptying as part of its therapeutic action, which can lead to increased distension of the stomach
Experts also note that these weight loss injections arent meant to work in isolation
Repeated large meals while digestion is slowed may increase the risk of longer-term problems, as chronic overstretching and impaired motility stress the stomachs muscles and nerves
Individuals using oral tirzepatide formulations or sublingual tirzepatide face additional bioavailability considerations that make microdose calculations even more complex
Others require a higher dose to get the full appetite-suppressing effect
Many patients find semaglutide gentler because its digestion changes develop more gradually
