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There is no strong evidence that Ozempic (semaglutide) directly causes missed periods that came out of the clinical trials, but some case reports and user surveys have described menstrual changes in women using Ozempic

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Orlistat and empagliflozin were selected as negative controls based on their similarity in the population indicated for GLP-1RAs, without any reported evidence of self-harm or suicide potential in the specification or related studies