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Yes, in research

[4] Clinical assessment should focus on identifying the cause of elevated levels rather than assuming toxicity from supplementation alone

171 Taken together, these findings illustrate that phytochemicals, such as flavonoids (galangin, SKN), terpenoids (triptolide), phenolic acids (canolol, CGA), and polyphenols, act as potent antioxidants in the GI tract

In particular, GLP1 increases glucose stimulated insulin secretion, functional pancreatic -cell mass and decreases glucagon secretion from pancreatic -cells

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Without a control group, it is impossible to determine whether the supplement contributed to these results or whether the lifestyle changes were responsible