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We felt it was important to document her clinical course to inform clinicians facing similarly complex patients. Indeed, children with early-onset obesity develop insulin resistance, liver dysfunction, and beta cell decline much more rapidly than adults because their organs and metabolic systems are developing, which makes them more vulnerable to the harmful effects of excess adiposity

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With the results of this large-scale clinical trial as evidence, semaglutide was approved by the FDA for marketing less than four months after the release of the phase 3 clinical results

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