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The assay is based on the conversion of citrate to isocitrate, to -ketoglutarate, which results in the production of NADPH

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The most common ones among real-world patients seem to be headaches, nausea, dizziness, and injection site redness or irritation that should subside with use

Injecting in a post-absorptive state keeps the signaling environment cleaner and consistent across all 10 doses

Dixon's group demonstrated that the GSH exporter MRP1 sensitizes HPA1 erastin-treated cells to ferroptosis and concordantly, MRP1 inhibition leads to a retention of GSH and leads to ferroptosis resistance (58)

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