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Take tirzepatide (the active ingredient in Zepbound)
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The timing concern is purely mechanical, related to gastric emptying rate and pH exposure
doi: 10.3329/bmrcb.v35i1.2132 65 Alvarez-ParrillaEde la RosaLALegarretaPSaenzLRodrigo-GarciaJGonzalez-AguilarGA
It could lead to increased adverse events
By addressing these pathways simultaneously, retatrutide is hypothesised to achieve greater efficacy in reducing body weight and improving cardiometabolic markers than single or dual receptor agonists
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