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Dermal injury drives a skin to gut axis that disrupts the intestinal microbiome and intestinal immune homeostasis in mice

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The total radioactivity concentrations in the intestine, skin, and lungs were similar to those in the plasma, and the mean concentrations in the gonads, myocardium, skeletal muscle, brain, and body fat were all lower than the mean concentrations in the plasma

This contraindication mirrors the warnings on GLP-1 receptor agonists and reflects precautionary data from animal studies rather than confirmed human risk

10.1016/j.addr.2023.114763 86

In the lab, it has been investigated extensively in animal and cell models for its purported regenerative, cytoprotective, and angiogenic effects