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IGF-1 LR3 contains a 13-amino-acid N-terminal extension and a glutamic acid substitution at position 3, reducing binding affinity for IGF-binding proteins (IGFBPs) by approximately 100-fold compared to endogenous IGF-1
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Based on the remaining trial schedule plus the FDA's standard 12-month review, the most defensible approval window is late 2027 to 2028
Representative IHC images (n) (20x magnification) and H-score quantification (o) of CD45 in Karpass299 tumours injected daily with HBSS or combined enzymes (10 U/mL)
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Aronoff, H
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