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It is because there are no clinical trial data to inform a recommendation either way
This result warrants caution: oral bioavailability of hexapeptides is generally very low due to gastrointestinal degradation and poor intestinal absorption, and the finding has not been widely replicated or supported by pharmacokinetic data confirming systemic absorption at meaningful levels
This effect is mediated by GSH-dependent conjugation and export of anticancer drugs, diminishing their intracellular concentrations and therapeutic efficacy (5053)
However, tirzepatide generally produces superior weight loss outcomes, so the decision involves weighing consistency against efficacy
In another study, the novel small lipotripeptides DICAMs, which are non-cationic fatty amine-tripeptide conjugates, effectively prevented the formation of biofilms by breaking down biofilms and eliminating the biofilm-affixed bacteria [91]
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