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Figure 9 Regression analysis revealed that single exercise time had a significant negative moderating effect on cognitive function in elderly individuals (b = 0.02, SE = 0.01, 95% CI [0.03, 0.001], p = 0.0335

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These pseudo-observations serve to anchor the doseresponse relationship at a physiologically plausible baseline (i.e., no treatment effect in the absence of exposure), thereby preventing unrealistic extrapolation near zero dose

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Acute illness, particularly bacterial infections, can cause stress hyperglycemia and alter insulin sensitivity, necessitating closer glucose monitoring during the treatment period