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He said: It is well established that better mental health tends to follow from better physical health and since the 1880s we have known that diabetes is associated with depression, although I think its unlikely that using GLP-1R agonists alone as treatments for depression or anxiety will work. Prof Eduard Vieta, a professor of psychiatry at the University of Barcelona and editor in chief of the European College of Neuropsychopharmacology journal, said: From a clinical perspective, these findings are reassuring regarding the psychiatric safety of GLP-1 receptor agonists and suggest a potential role not only in preventing worsening but also, possibly, in improving mental health outcomes

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Designing future studies may require careful attention to which endpoint is primary, as that will dictate whether a lower, moderate, or higher dose is emphasised

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