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Several animal experiments and clinical trials have demonstrated that GLP-1R agonists are more effective in treating or preventing obesity

An important signal in the noise is this piece just published in BMJ

The drugs only work when they are taken. Whether or not you commit to a lifetime of taking a GLP-1 medication for weight loss, taking care of yourself goes far beyond a pill or injection

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This is achieved by virtue of their metabolic effects and reduction of body weight through their central actions of increased satiety and reduced food intake (see Figure 1), thus rendering them highly effective therapies

A dramatic improvement in metabolic markers without a corresponding explanation (new diet, exercise program, other medication changes) may prompt questions