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Although uncontrolled hypothyroidism is associated with increased stroke risk via mechanisms, such as increased vascular resistance, endothelial dysfunction, dyslipidemia, and a pro-thrombotic state [68], the increased stroke risk may be attenuated by the potential cerebrovascular protective effects of GLP-1RA [69]
To reduce its impact: Eat smaller, more frequent meals rather than large portions Eat slowly and stop before feeling overly full Avoid rich, fatty, or heavily spiced foods during the adjustment period Stay well hydrated, particularly if experiencing diarrhoea Avoid lying down immediately after eating Most gastrointestinal symptoms improve within two to four weeks as the body adjusts to the current dose
1 Heart-rate changes can persist longer but tend to plateau or decline as treatment continues
There is no weight-based dosing
If the question is "what does the science suggest is coming," retatrutide's phase 2 weight-loss and liver-fat numbers are genuinely notable but "promising in phase 2" and "proven and approved" are very different standards, and the gap between them is exactly what phase 3 exists to test
Still, Gendreau says these products are no better than ultra-processed foods
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