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The Phase 2 results published in the New England Journal of Medicine generated significant buzz, and the TRIUMPH-4 Phase 3 confirmation elevated that interest further
With the implicit validity of these data given the expected weight regain seen after therapy cessation, there is some credence to the idea that this is a genuine reflection of nondurability of weight loss with GLP-1 receptor agonist therapy
GLP-1 receptor agonists have been studied for over a decade in both diabetes and weight management populations, with long-term trials showing consistent benefits beyond the first year of treatment
Most patients see initial improvements within 3-4 weeks , with continued progress over months
Margarita Lolis, MD,, is a board-certified and fellowship-trained dermatologist and Mohs surgeon specializing in cosmetic and medical dermatology at Schweiger Dermatology Group Ashley Magovern, MD, is a board-certified dermatologist and the medical advisor for Dermstore
Review authors noted that it may prevent the development of or help manage conditions, including dementia, Parkinsons disease, and cardiovascular disease
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