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This limited perspective has somewhat hindered the exploration of the ferroptosis regulatory system as a target for cancer therapy

[30] Cobalamin analogs prepared by this method include the naturally occurring coenzymes methylcobalamin and cobamamide, and other cobalamins that do not occur naturally, such as vinylcobalamin, carboxymethylcobalamin and cyclohexylcobalamin

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5H, I), while overexpression of a codon-optimized L2HGDH (L2HGDH OPT ), which is resistant to the designed sgRNA, reverses this effect (Fig

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However, this participant had a slower dose titration due to their heart failure, so took longer to reach the maximum dose