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The question of tolerability and adherence ultimately led to investigating oral forms of GLP-1 RAs

Increased sweating may be reported, particularly at higher doses

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A 2026 study in Cell Reports Medicine found that GLP-1 medications predominantly reduce body fat, with a smaller but significant decrease in lean mass

Future research directives should focus on (1) developing subgroup-specific predictive modelssuch as designing a scoring system for remission probability that incorporates factors like disease duration, BMI, and HOMA-that can offer clinicians more accurate guidance for selecting treatment plans