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The activation of non-canonical pyroptotic pathways frequently occurs upon gram-negative bacterial infection (163)

Catalase activity increases for hydrogen peroxide breakdown, and total glutathione levels rise, creating stronger hydroxyl radical quenching capacity than glutathione alone

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Without adequate baroreceptor reflex induced vasoconstriction, blood pools in the lower extremities, resulting in orthostatic hypotension, with reduced cerebral blood flow, and dizziness or fainting