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A landmark review published in Biomolecules documenting GHK-Cus regulatory effects on over 4,000 human genes, including significant upregulation of collagen synthesis, anti-inflammatory pathways, and stem cell mobilization established the molecular basis for its clinical use
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[26] In addition, glutamate plays important roles in the regulation of growth cones and synaptogenesis during brain development as originally described by Mark Mattson
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