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This stress leads to suppression of forkhead box O1 (FoxO1) signaling and subsequent upregulation of thioredoxin interacting protein, inhibition of insulin and SOD-2 expression, re-expression of Neurog3, and -cell dedifferentiation and functional failure
Thiol chemistry and specificity in redox signaling
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In hindlimb ischemia models, the peptide accelerates blood flow recovery as measured by laser Doppler scanning, with histological analysis confirming increased vessel numbers and enhanced vascular expression of VEGFR2
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10.1002/mnfr.202400227 35 KanwalF.KramerJ
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