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As mitochondria fail to maintain cellular energy, neuronal survival is compromised, and apoptotic pathways are activated (Davidson et al., 2001) (Figure 1)
In the STEP (Semaglutide Treatment Effect in People with obesity) programme, participants using higher doses of semaglutide (2.4 mg weekly, marketed as Wegovy) achieved average weight reductions of 12-15% over 68 weeks when combined with lifestyle interventions
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It also maximizes its glutathione content
Mood disturbances including irritability, depression, or unusual anxiety
