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Patients should be advised to report any worsening of digestive symptoms promptly, and dose titration may need to be slower than standard protocols to optimise tolerance
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However, sensitivity analyses excluding this higher-risk study yielded comparable pooled estimates, and leave-one-out analyses showed consistent direction of effect across all exclusions
(PubMed) Hart AM, Wilson AD, Montovani C, et al
Evidence-Based Complementary and Alternative Medicine : ECAM, 2019 , 7861297
Teichman and colleagues, for example, documented prolonged and amplified GH and IGF-1 secretion using a long-acting GHRH analog, illustrating how the GHRH side of the equation can be optimized
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